Publications
• Norwitz NG, Soto-Mota A. Carnivore-Ketogenic diet for treatment of inflammatory bowel disease: a case series of 10 patient. Front Nutr 2024; doi: 10.3389/fnut.2024.1467475 (Video abstract)
• Budoff M, Manubolu VS, Kinninger A, Norwitz NG, Feldman D, Wood TR,CuryR, Feldman T, Fialkow J, Nasir K. Carbohydrate restriction-induced elevations in LDL-cholesterol and atherosclerosis: The KETO trial. JACC Advances 2024;doi: 10.1016/j.jacadv.2024.101109 (Video abstract)
• Javier DA, Manubolu VS, Kinninger A, Norwitz NG, Aldana JB, Ghanem A, Ahmad K, Vicuna WD, Hamidi H, Bagheri M, Villanueva B, Flores F, Hamal S, Feldman D, Budoff, MJ. The impact of carbohydrate restriction-induced elevations in LDL cholesterol on progression of coronary atherosclerosis: the ketogenic diet trial study design. Coronary Artery Disease 2024; doi: 10.1097/MCA. 0000000000001395
• Cayabyab KB, Shin MJ, Heimuli MS, Kim IJ, D’Agostino Dominic P., Johnson RJ, Koutnik AP, Bellissimo N, Diamond D, Norwitz NG, Arroyo JA , Reynolds PR, Bikman BT. The Metabolic and Endocrine Effects of a 12-Week Allulose-Rich Diet. Nutrients. 2024; doi: https://doi.org/10.3390/nu16121821
• Norwitz NG, Cromwell WC. Oreo cookie treatment lowers LDL cholesterol more than high-intensity statin therapy in a lean mass hyper-responder on a ketogenic diet: A curious crossover experiment. Metabolites. 2024; doi: 10.3390/metabo14010073 (Video abstract)
• Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. Amer J of Clin Nutr. 2024; doi: 10.1016/j.ajcnut.2024.01.009 (Video abstract)
• Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Reply to P Phalak et al. Amer J Clin Nutr. 2024. doi: 10.1016/j.ajcnut/2024.02.011
• Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Reply to JT Gonzalez et al. and M Kamikski and P Jarecki. Amer J Clin Nutr. 2024. doi: 10.1016/j.ajcnut.2024.05.015
• Sota-Mota A, Jansen L, Norwitz NG, Pereira M, Ebeling C, Ludwig DS. Physiological Adaptation to Macronutrient Change Distorts Findings from Short Dietary Trials: Reanalysis of a Metabolic Ward Study. J Nutr 2023. doi: 10.1016/j.tjnut.2023.12.017 (Video abstract)
• Soto-Mota A, Jansen L, Norwitz NG, Pereira M, Ebeling C, Ludwig DS. Reply to C M Sciarrilo et al. J Nutr 2024. doi: 10.1016/j.tjnut.2024.01.026
• Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Front Endocrinol 2023; 14:1-7. doi: 10.3389/fendo.2023.1326768
• Norwitz NG, Hurn M, Forcen FE. Animal-based ketogenic diet puts severe anorexia nervosa into multi-year remission: a case series. J Metab Health 2023; 6:a84. doi: 10.4102/jir.v6i1.84
• Norwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. J Clin Lipidol 2022; 16:765-768. doi: 10.1016/j.jacl.2022. 10.010
• Norwitz NG, Czeisler ME, Delichatsios HK, Hoenig MP, Cywes R. Metabolic health immersion for medical education: a pilot program with continuous glucose monitors in Harvard medical and dental students. Am J Lifestyle Med 2023; 17:782-790. doi: 10.1177/15598276221119989
• Feldman D, Huggins S, Norwitz NG. Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower LDL cholesterol: the cholesterol drop experiment. Curr Opin Endocrinol Diabetes Obes 2022; 29:434-439. doi: 10.1097/MED.0000000000000762
• Norwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites 2022; 12:460. doi: 10.3390/metabo12050460 (video abstract)
§ This hypothesis paper reviews a model we developed to explain the LMHR phenotype.
• Norwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Curr Dev Nutr 2021; 6:nzab144. doi: 10.1093/cdn/nzab144
• Ludwig DS, Norwitz NG, Feldman D, Soto-Mota A, Kalayjian. Reply to M Mindrum and J Moore et al. Curr Dev Nutr 2022. doi: 10.1093/cdn/nzac029
• Norwitz NG, Soto-Mota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyper-responder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Front Endocrinol 2022; 13:830325. doi: 10.3389/fendo.2022.830325
• Norwitz NG, Saif N, Ariza IE, Isaacson RS. Precision nutrition for Alzheimer’s prevention in ApoE4 carriers. Nutrients 2021; 13:1362. doi: 10.3390/nu13041362 (video abstract)
• Mota AS, Norwitz NG, Evans R, Clarke K. Exogenous D-β-hydroxybutyrate lowers blood glucose in part by decreasing the availability of L-alanine for gluconeogenesis. Endocrinol Diabetes Metab 2022; 5:e00300. doi: 10.1002/edm2.300
• Mota AS, Norwitz NG, Evans R, Barber TM. Exogenous ketosis in patients with type II diabetes: safety, tolerability, and effect on glycemic control. Endocrinol Diabetes Metab 2021; 4:e00264. doi: 10.1002/edm2.264
• Norwitz NG, Winwood R, Stubbs BJ, D’Agostino DP, Barnes PJ. Case report: ketogenic diet is associated with improvements in chronic obstructive pulmonary disease. Front Med 2021; 8:699427. doi: 10.3389/fmed.2021.699427
• Norwitz NG, Naidoo U. Nutrition as a metabolic treatment for anxiety. Front Psychiatry 2021; 12:598119. doi: 10.3389/fp-syt.2021.598119
• Norwitz NG, Loh V. A standard lipid panel is insufficient for a patient on a high-fat, low-carbohydrate ketogenic diet. Front Med 2020; 7:97. doi: 10.3389/fmed.2020.00097
• Norwitz NG, Sethi S, Palmer C. Ketogenic diet as a metabolic treatment for mental illness. Curr Opin Endocrinol Diabetes Obes 2020; 27:269-274. doi: 10.1097/MED.0000000000000564 (video abstract)
• Norwitz NG, Dearlove DJ, Lu M, Clarke K, Dawes H, Hu MT. A ketone ester drink enhances endurance exercise performance in Parkinson’s disease. Front Neurosci 2020; 14:584130. doi: 10.3389/fnins/2020/584130
• Norwitz NG, Querfurth H. mTOR mysteries: nuances and questions about the mechanistic target of rapamycin in neurodegenerative disease. Front Neurosci 2020; 14:775. doi: 10.3389/fnins.2020.00775
• Mota AS, Norwitz NG, Clarke K. Why a D-b-hydroxybutyrate monoester? Biochem Soc Trans 2020; 48:51-59. doi: 10.1042/BST20190240
• Norwitz NG, Jaramillo JG, Clarke K, Mota AS. Ketotherapeutics for neurodegenerative disorders. International Review of Neurobiology. 2020; 155: 141-168. doi: 10.1016/bs.irn.2020.02.003.
• Norwitz NG, Hu MT, Clarke K. The mechanisms by which the ketone body D-b-hydroxybutyrate may improve the multiple cellular pathologies of Parkinson’s disease. Front Nutr 2019; 6:63. doi:10.3389/fnut.2019.00063
• Norwitz NG, Mota AS, Norwitz SG, Clarke K. Multi-loop model of Alzheimer disease: an integrated perspective on the Wnt/GSK3b, a-synuclein, and type 3 diabetes hypotheses. Front Aging Neurosci 2019; 11:184. doi: 10.3389/fnagi.2019.00184
• Norwitz NG, Mota AS, Misra M, Ackerman KE. LRP5, bone density, and mechanical stress: a case report and literature review. Front Endocrinol 2019; 10:184. doi: 10.3389/fendo.2019.00184